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(2017) further supported rutins antidepressant potential by observing a dose-dependent decrease in immobility time during the tail suspension test (TST) in mice treated with rutin (Yushau et al., 2017) (Figure 3)

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Patients are educated on avoiding triggers such as shift work, alcohol, tobacco, prolonged bed rest, weight gain, lack of sleep, and stress, while promoting strategies to manage fatigue including increasing exercise, consuming nocturnal protein snacks, and employing ergogenic nutrition ( Pharmacological treatments, however, have shown limited evidence of effectiveness in alleviating fatigue

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